Nature articles s41419 023 06389 5 Mechanisms of immune checkpoint inhibitors insights into the Jan 4 2024 One of the most substantial advances in cancer therapy in the last decades was the discovery of a new layer of immunotherapy approach immune checkpoint inhibitors
Science AAAS doi 10 Anti phagocytosis blocking repolarization resistant membrane Aug 9 2023 Here we present a core shell anti phagocytosis blocking repolarization resistant membrane fusogenic liposome ARMFUL to achieve one step multiplexing cell engineering
Nature articles s41573 021 00155 y Beyond immune checkpoint blockade emerging Nature Mar 8 2021 Emerging insights into tumour biology suggest that successful future therapeutics will focus on two key factors rescuing T cell homing and dysfunction in the TME and
JACC Journals doi 10 Immune Checkpoint Inhibitor Therapy in Oncology The development of immune checkpoint inhibitors ICIs culminated decades of searching for the elusive keys to activating host immunity to regulate cancer growth These
Cancer Cell International articles 10 Immune checkpoint blockade in the treatment of malignant Nov 2 2021 Immunotherapy with immune checkpoint inhibitors ICIs has modified the therapeutic strategy to malignant tumors and emerge as a rapidly developing area of research It
BRAF a tumour agnostic drug target with l www nature com articles s41571 023 00852 0 See all results for this question Does circst6galnac6 bind to HSPB1 In the context of bladder cancer circST6GALNAC6 has been shown to bind to small heat shock protein 1 HSPB1 and block erastin induced phosphorylation site of HSPB1 protectively in response to ferroptosis stress Ser 15 site thus activating the P38 MAPK pathway and facilitating cell ferroptosis
Nature articles s41571 023 00852 0 BRAF a tumour agnostic drug target with lineage specific Jan 26 2024 In this Review we discuss the underlying mechanisms through which BRAF mutations activate MAPK signalling and govern sensitivity to BRAF inhibitors and how insights
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Mechanisms of immune checkpoint inhibitors www nature com articles s41419 023 06389 5 See all results for this question Does micro environment elicit innate resistance to Raf inhibitors through HGF secretion Straussman R et al Tumour micro environment elicits innate resistance to RAF inhibitors through HGF secretion Nature 487 500 504 2012 Fedorenko I V Wargo J A Flaherty K T Messina J L Smalley K S M BRAF inhibition generates a host tumor niche that mediates therapeutic escape
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American Association of Immunologists immunohorizons article Recent Advances in the Development of Monoclonal Antibodies Dec 27 2023 Along with hybridoma technology several novel and alternative methods have been developed to improve mAb generation ranging from electrofusion to the discovery of
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